High Quality Genome-Wide
Genotyping from Archived Dried Blood Spots without DNA Amplification
Krystal R. St. Julien et al. PLoS ONE, May 2013, 8(5): e64710. doi:10.1371/journal.pone.0064710
Krystal R. St. Julien et al. PLoS ONE, May 2013, 8(5): e64710. doi:10.1371/journal.pone.0064710
Abstract
Spots
of blood are routinely collected from newborn babies onto filter paper called Guthrie
cards and used to screen for
metabolic and
genetic disorders. The archived dried blood spots are an important and precious
resource for genomic
research.
Whole genome amplification of dried blood spot DNA has been used to provide DNA
for genome-wide SNP
genotyping.